研究领域

许韧教授长期聚焦于运动系统干/祖细胞及其微环境的调控机制，深入探究靶向成骨化细胞构建的临床潜能，并首次在四大医学杂志（Lancet, 2024）上提出新型骨骼干细胞的临床转化潜能。其中核心工作为：在国际上首次发现感觉神经调控成骨功能的分子机制（Nature, 2013; Nature Communications, 2021）；率先提出基于组织特异性血管为靶点的骨病防治理念（Nature Medicine, 2018; Bone Research, 2020）；绘制首个人类和小鼠早期椎间盘形成的时空转录图谱(Advanced Science, 2023；Advanced Science, 2024); 多维度解析新型促成骨化靶点“Schnurri-3”的系统生物学功能(Pharmacological Research, 2023; Journal of Orthopaedic Translation, 2024; Bone Research, 2024; Nature Communications, 2024)。

主要研究方向如下：

1）运动系统干/祖细胞亚型的鉴定及其分化等级

2）神经/血管网络在运动系统疾病中的作用机制与临床潜能

3）成骨化分泌因子在机体代谢类疾病中的系统生物学调控功能

学习经历

2001-2005 安徽师范大学生命科学学院，学士（生物技术）

2005-2008 厦门大学生命科学学院，硕士（微生物药物学）

2008-2013 日本东京科技大学，博士（骨外科学）

工作经历

2013-2014 日本东京医科齿科大学附属医院, 特任研究员

2014-2019 美国康奈尔大学纽约国际手机登录 ，博士后研究员

2019-至今 纽约国际手机登录，教授、博士生导师

代表性成果（* 通讯；^# 并列第一）

(1) Weinan Cheng, Jianming Huang, Na Li, Ren Xu*. Skeletal stem-cell

therapy: challenge meets opportunity, Lancet, 2024, Jan 20; 403 (10423):243.

(2) Zan Li#; Baohong Shi#; Na Li#; Jun Sun; Xiangchen Zeng; Rui Huang; Seoyeon Bok; Xiaohui Chen; Jie Han; Alisha R. Yallowitz; Shawon Debnath; Michelle Cung; Zheng Ling; Chuan-Qi Zhong; Yixang Hong; Gang Li; Mascha Koenen; Paul Cohen; Xinhui Su; Hongbin Lu; Matthew B. Greenblatt; Ren Xu*; Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion, Nature Communications, 2024, 15(1): 6697

(3) Na Li#; Baohong Shi#; Zan Li; Jie Han; Jun Sun; Haitao Huang; Alisha R Yallowitz; Seoyeon Bok; Shuang Xiao; Zuoxing Wu; Yu Chen; Tian Qin; Rui Huang; Haiping Zheng; Rong Shen; Lin Meng; Matthew B Greenblatt; Ren Xu*; Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta, Bone Research, 2024, 12(1): 46（封面文章）

(4) Yu Chen#, Zhang Long#, Xueqing Shi#, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew B. Greenblatt, Rongqin Ke*, Jianming Huang*, Zhe-Sheng Chen*, Ren Xu*. Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics, Advanced Science, 2024, 2303752

(5) Xie Chunlan#, Yue Yuting#, Xu Jingping, Li Na, Lin Ting, Ji Guangrong*, Yang Xianwen*, Xu Ren*. Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway, Pharmacological Research, 2023, 197:106968

(6) Sun Jun#, Shin Dongyeon#, Eiseman Mark, Yallowitz AlishaR, Li Na, Lalani Sarfaraz, Li Zan, Cung Michelle, Bok Seoyeon, Debnath Shawon, Marquez Ssofia Jenia, White Tommy E., Khan Abdul G., Lorenz Ivo C., Shim Jae-Hyuck, Lee Francis S., Xu Ren*, Greenblatt Matthew B.* SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, Nature Communications, 2021, 12(1):4611

(7) Na Li#, Kazuki Inoue#, Jun Sun, Yingzhen Niu, Sarfaraz Lalani, Alisha Yallowitz, Xu Yang, Chao Zhang, Rong Shen, Baohong Zhao, Ren Xu*, Matthew B. Greenblatt. Osteoclasts are not a source of SLIT3, Bone Research, 2020, 8(1):11

(8) Ren Xu , Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P. Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G. Poulos1, Amanda Wach, Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M. Butler, Jae-Hyuck Shim, Laurie H. Glimcher*, Matthew B. Greenblatt*, Targeting skeletal endothelium to ameliorate bone loss, Nature Medicine, 2018, 24(6):823-833

(9) Toru Fukuda#, Shu Takeda#*, Ren Xu#, Hiroki Ochi, Satoko Sunamura, Tsuyoshi Sato, Shinsuke Shibata, Yutaka Yoshida, Zirong Gu, Ayako Kimura, Chengshan Ma, Cheng Xu, Waka Bando, Koji Fujita, Kenichi Shinomiya, Takashi Hirai, Yoshinori Asou, Mitsuhiro Enomoto, Hideyuki Okano, Atsushi Okawa,Hiroshi Itoh, Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013,497(7450):490-3

承担的重要课题

1.国家自然科学基金重大研究计划-重点项目，神经纤维亚型在骨骼干细胞生态位（Niche）中的调控机制研究，92468203，220万，2025-01至2028-12，主持

2.国家自然科学基金面上项目，Schnurri-3在骨调控机体能量代谢中的作用机制研究，82372362，49万，2024-01至2027-12，主持

3.国家重点研发计划-干细胞及转化研究项目，间充质干细胞新功能性亚群的鉴定及调控机制，2020YFA0112901，372万，2020-10至2024-12，主持

4.国家自然科学基金重大研究计划-培育项目，SLIT2介导的神经嵌入在骨骼干细胞命运归属和成骨化进程中的作用机制研究，92068104，79万，2020-01至2023-12，主持

5.国家自然科学基金面上项目，SLIT3介导的血管亚型在骨骼干细胞微环境中的作用机制研究，81972034，55万，2020-01至2023-12，主持

6.福建省自然科学基金杰出青年基金项目，骨骼干细胞的神经纤维微环境及其调控机制，2022J06003，30万，2022-08至2025-08，主持

7.中国共产党中央委员会组织部海外高层次人才引进计划青年项目， K2921003， 海外高层次人才引进计划青年项目（运动医学），200万元， 2021-09 至 2026-09，主持

8.厦门大学“南强青年拔尖A类人才”启动经费，300万元，2019-09至2024-12），主持

获奖及荣誉

1. 2013 日本文部省（教育部）全球杰出研究计划-“骨与齿分子机制”的超级学生

2. 2017 国际华人骨研会（ICMRS）Webster Jee青年学者奖

3. 2018 国际骨免疫学会青年学者奖

4. 2018 福建省“闽江学者”奖励计划

5. 2019 美国 John Haddad 青年学者奖（全球十人）

6. 2021 中组部国家级重大人才计划青年项目入选者

7. 2022 福建省自然科学基金杰出青年项目获得者

8. 2023 中华医学会第二十二届骨科学术会议暨第十届COA学术大会骨科基础青年学者比赛第一名

学术兼职

现为国际华人骨研学会（ICMRS）终身会员、美国骨研究促进会（AIMM）会员、中国细胞生物学会发育生物学分会委员、中国生理学会基质生物学专委会委员、中国医师协会骨科分会基础与转化学组委员；

担任Annals of Joint杂志执行主编，Bone Research、Bone、Journal of Orthopaedic Translation等多本骨科杂志的编委；受邀在Lancet、 Elife、Protein & Cell等国内外权威期刊撰写综述与评论文章。

社会兼职

厦门市政协委员、农工党厦门市委副主委

所有论文列表

(1) Zan Li#; Baohong Shi#; Na Li#; Jun Sun; Xiangchen Zeng; Rui Huang; Seoyeon Bok; Xiaohui Chen; Jie Han; Alisha R. Yallowitz; Shawon Debnath; Michelle Cung; Zheng Ling; Chuan-Qi Zhong; Yixang Hong; Gang Li; Mascha Koenen; Paul Cohen; Xinhui Su; Hongbin Lu; Matthew B. Greenblatt; Ren Xu* ; Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion, Nature Communications, 2024, 15(1): 6697

(2) Na Li#; Baohong Shi#; Zan Li; Jie Han; Jun Sun; Haitao Huang; Alisha R Yallowitz; Seoyeon Bok; Shuang Xiao; Zuoxing Wu; Yu Chen; Tian Qin; Rui Huang; Haiping Zheng; Rong Shen; Lin Meng; Matthew B Greenblatt; Ren Xu*; Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta, Bone Research, 2024, 12(1): 46

(3) Yu Chen#, Zhang Long#, Xueqing Shi#, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew B. Greenblatt, Rongqin Ke*, Jianming Huang*, Zhe-Sheng Chen*, Ren Xu*. Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics, Advanced Science, 2024, 2303752

(4) Weinan Cheng; Jianming Huang; Na Li; Ren Xu*; Skeletal stem-cell therapy: challenge meetsopportunity, Lancet, 2024, 403(10423): 243

(5) Guixin Yuan#, Xixi Lin#, Ying Liu#, Matthew B. Greenblat*, Ren Xu*, Skeletal stem cells in bone development, homeostasis, and disease, Protein & Cell, 2024, DOI10.1093/procel/pwae008

(6) Zan Li#, Xiangchen Zeng#, Baohong Shi#, Jie Han, Zuoxing Wu, Xiaohui Chen, Long Zhang, Na Li, Matthew Greenblatt, Jianming Huang*, Ren Xu*. Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow, Journal of Orthopaedic Translation, 2024, 45:168-177

(7) Xixi Lin#, Guixin Yuan#, Bin Yang#, Chunlan Xie, Zhigao Zhou, Ying Liu, Zhijuan Liu, Zuoxing Wu, Yoshie Akimoto, Na Li, Ren Xu*, Fangming Song*,Dauricine attenuates ovariectomized-induced bone loss and RANKL-induced osteoclastogenesis via inhibiting ROS-mediated NF-κB and NFATc1 activity, Phytomedicine, 2024, 126:155559

(8) Long Zhang#, Weibin Li#, Xiaohui Chen#, Dongmin Cao#, Siyuan You, Fan Shi, Zhengqiong Luo, Hongyu Li, Xiangchen Zeng, Yabin Song, Na Li, Yoshie Akimoto, Gang Rui, Yu Chen*, Zuoxing Wu*, Ren Xu*. Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signaling, Chemico-Biological Interactions, 2024, 394:110986

(9) Long Zhang#, Xieqing Shi#, Xiaohui Chen#, Gang Rui, Na Li, Yoshie A Kimoto, Mingxia Zhang, Yu Chen*, Ren Xu*. Development, Validation and Characterization of a Novel Portable Closed Fracture Device, in vivo, 2024, 38:134-146

(10) Zuoxing Wu#, Xixi Lin#, Guixin Yuan#, Na Li*, Ren Xu*. Innate lymphoid cells: New players in osteoimmunology, European Journal of Immunology, 2024, 0:2350381

(11) Bei’er Ma, Ren Xu*. Dental pulp regeneration via dental pulp stem cells conditioned media and curcumin-loaded nanocomposite hydrogel: an in vitro and in vivo study, Materials Science-Poland, 2024, 42(2): DOI10.2478/msp-2024-0018

(12) Yanhui Zhu#, Qingxiang Gao#,  Jia Zhang, Yu Cheng, Shuzhen Yang, Ren Xu, Jing Yuan, Boris Novakovic, Mihai G. Netea*, Shih-Chin Cheng*, Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling, Cell Reports, 2024, 43(0): DOI10.1016/j.celrep.2024.114850

(13) Chun-Lan Xie, Tai-Zong Wu, Yuan Wang, Robert J. Capon, Ren Xu,  Xian-Wen Yang, Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity, Organic Letters, 2024, 26(18):3889-3895

(14) Xie Chunlan#, Yue Yuting#, Xu Jingping, Li Na, Lin Ting, Ji Guangrong*, Yang Xianwen*, Xu Ren*. Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway, Pharmacological Research, 2023, 197:106968

(15) Taifeng Zhou#, Yu Chen#, Zhiheng Liao#, Long Zhang, Deying Su, Zhuling Li, Xiaoming Yang, Xiaona Ke, Hengyu Liu, Yuyu Chen, Ricong Weng, Huimin Shen, Caixia Xu, Yong Wan, Ren Xu*, Peiqiang Su*. Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single-Cell Resolution. Advanced Science, 2023, 10(14):2206296

(16) Zhang Long#, Chen Xiaohui#, Shi Xueqing#, Zhang Mingxia, Li Na, Rui Gang, Chen Yu*, Xu Ren*. Establishment and evaluation of a modified mouse model of renal subcapsular transplantation of microvolume cells, Biochemical and Biophysical Research Communicaitons, 2023, 681:165-172, 2023

(17) Sun Jun, Hu Lingling, Bok Seoyeon, Yallowitz Alisha R., Cung Michelle, McCormick Jason, Zheng Ling J., Debnath Shawon, …., Bostrom Mathias P.G., Xu Ren, Lyer Sravisht, Greenblatt Matthew B*. A vertebral skeletal stem cell lineage driving metastasis, Nature, 2023, 621: 602–609

(18) Wang Hai#, Liu Jing#, Wu Zuoxing, Zhao Yangyang, Cao Man, Shi Baohong, Chen Ning, Guo Hao, Chen Jian*, Xu Ren*. Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis, Gut Pathogens, 2023, 15(1):33

(19) Yallowitz Alisha R., Shim Jae-Hyuck, Xu Ren, Greenblatt Matthew B*. An angiogenic approach to osteoanabolic therapy targeting the SHN3-SLIT3 pathway, Bone, 2023, 172:116761

(20) Wu Zuoxing#, Li Xuedong#, Chen Xiaohui#, He Xuemei#, Chen Yu, Zhang Long, Li Zan, Yang Mengyu, Yuan Guixin, Shi Baohong, Chen Ning, Li Na, Feng Haotian, Zhou Mengyu*, Rui Gang*, Xu Feng*, Xu Ren*. Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis, Frontiers in Pharmacology, 2023, 13:1021714

(21) Zhi-Hui He, Chun-Lan Xie, Taizong Wu, Yu-Ting Yue, Chao-Feng Wang, Lin Xu, Ming-Min Xie, Yong Zhang, You-Jia Hao, Ren Xu*, Xian-Wen Yang*, Tetracyclic Steroids Bearing a Bicyclo[4.4.1] Ring System as Potent Antiosteoporosis Agents from the Deep-Sea-Derived Fungus Rhizopus sp. W23, Journal of Natural Products, 2023, 86:157-165

(22) Kazuki Inoue#, Yongli Qin#, Yuhan Xia#, Jie Han, Ruoxi Yuan, Jun Sun, Ren Xu, Jean X Jiang, Matthew B Greenblatt, Baohong Zhao, Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass, eLife, 2023, 12:e82118

(23) Long Zhang, Na Li, Ren Xu*.Where it all started, eLife, 2023, 12:e87355

(24) Zhihui He#, Chunlan Xie#, Taizong Wu#, Yong Zhang, Zhengbiao Zou, Mingmin Xie, Lin Xu, Robert J. Capon, Ren Xu, Xianwen Yang*. Neotricitrinols A–C, unprecedented citrinin trimers with anti-osteoporosis activity from the deep-sea-derived Penicillium citrinum W23, Bioorganic Chemistry, 2023, 139:106756

(25) Yong Zhang#, Chunlan Xie#, Yuan Wang, Xiwen He, Mingmin Xie, You Li, Kai Zhang, ZhengBiao Zou, Longhe Yang, Ren Xu*, Yang Xianwen*.Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities, Marine Drugs, 2023, 21:538

(26) Yingwen Chen#, Xuanqun Wang#, Xing Na#, Yingkun Zhang#, Zan Li, Xiaohui Chen, Linfeng Cai, Jia Song, Ren Xu*, Chaoyong Yang*. Highly Multiplexed, Efficient, and Automated Single-Cell MicroRNA Sequencing with Digital Microfluidics, Small Methods, 2023, 11: e2301250

(27) Guixin Yuan#, Zan Li#, Xixi Lin#, Na Li*, Ren Xu*. New perspective of skeletal stem cells, Biomaterials Translational, 2022, 3(4):280-294

(28) Long Zhang, Guicheng Du, Bogang Teng, Xueqing Shi, Xuemei  He, Na Li, Yu Chen*, Xu Ren. Vascular anatomy-based localization of intervertebral discs assisting needle puncture for constructing a mouse model of mechanical injury-induced lumbar intervertebral disc degeneration, Biochemical and Biophysical Research Communications, 2022, 634:196-202

(29) Wu Zuoxing#, Li Chen#, Chen Yu#, Liu Qian, Li Na, He Xuemei, Li Weibin, Shen Rong, Li Li, Wei Chenming, Shao Siyuan, Fu Fangsheng, Ding Jiaxin, Sun Xiaochen, Wang Dairong, Yuan Guixin, Su Yiji, Zhao Jinmin, Xu Jiake, Xu Ren*, Xu Xin*, Xu Feng*. Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling, Frontiers in Pharmacology, 2022, 13:793087

(30) Yongjie Chen#, Linlin Zhang#, Zongguan Li#, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui*, Ren Xu*, Guangrong Ji*. Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal Mice, Frontiers in Pharmacology, 2022, 13：1-14

(31) 林茜茜，张龙，袁桂鑫，吴佐星， 冯昊天， 李娜，许韧*. 骨骼干细胞的研究进展，厦门大学学报（自然科学版），2022, 61（3）：429-435

(32) Tuan Rocky S., Zhang Yingze, Chen Lin, Guo Quanyi, Yung Patrick SH., Jiang Qing,…, Xu Ren, Li Zhong Alan, Chen Di*, Qin Ling*. Current progress and trends in musculoskeletal research: Highlights of NSFC-CUHK academic symposium on bone and joint degeneration and regeneration, Journal of Orthopaedic Translation, 2022, 37: 175-184

(33) Kim Jung-Min, Yang Yeon-Suk, Hong Jaehyoung, Chaugule Sachin, Chun Hyonho, Marjolein CH van der Meulen, Ren Xu, Greenblatt Matthew B, Shim Jae-hyuck*. Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway, eLife, 2022, 11:e78069

(34) Guohui Liu*, Guozhi Xiao*, Jiacan Su*, Ren Xu*, Zhidao Xia*.Editorial: Tissue Stem Cells During Trauma: From Basic Biology to Translational Medicine, Frontiers in Cell and Developmental Biology, 2022, 10:915482

(35) Wenkai Chen#, Wenping Lin#, Naichun Yu#, Linlin Zhang#, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xiaohui Chen, Xu He, Yue Wu, Xiangchen Zeng, Yuting Yueh, Ren Xu *, Guangrong Ji *. Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect, International Journal of Nanomedicine, 2022, 17:5431-5446

(36) Sun Jun#, Shin Dongyeon#, Eiseman Mark, Yallowitz AlishaR, Li Na, Lalani Sarfaraz, Li Zan, Cung Michelle, Bok Seoyeon, Debnath Shawon, Marquez Ssofia Jenia, White Tommy E., Khan Abdul G., Lorenz Ivo C., Shim Jae-Hyuck, Lee Francis S., Xu Ren*, Greenblatt Matthew B.* SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, Nature Communications, 2021, 12(1):4611

(37) Vertesich K, Sosa BR, Niu Y, Ji G, Suhardi V, Turajane K, Mun S, Xu R, Windhager R, Park-Min KH, Greenblatt MB, Bostrom MP, Yang X. Alendronate enhances osseointegration in a murine implant model. J Orthop Res. 2020

(38) Sato T, Iwata T, Usui M, Kokabu S, Sugamori Y, Takaku Y, Kobayashi T, Ito K, Matsumoto M, Takeda S, Xu R, Chida D. Bone phenotype in melanocortin 2 receptor-deficient mice. Bone Rep. 2020 Aug 30;13:100713

(39) Li N, InoueK, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B, Xu R#, Greenblatt MB. Osteoclasts are not a source of SLIT3. Bone Res. 2020; 8, 11.

(40) Bok S, Shin DY, Yallowitz AR, Eiseman M, Cung M, Xu R, Li N, Sun J, Williams AL, Scott JE, Su B, Shim JH, Greenblatt MB. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. Nat Commun. 2020 Nov 11;11(1):5704.

(41) Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O,  Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 05 08;11(1) :10.1038/s41467-020-16038-6  

(42) Ji G*,Xu R*, Niu Y, Li N, Ivashkiv L, Bostrom MPG, Greenblatt MB, Yang X. Vascular endothelial growth factor pathway promotes osseointegration and CD31(hi)EMCN(hi) endothelium expansion in a mouse tibial implant model: an animal study. Bone Joint J. 2019 Jul;101-B:108-114.

(43) Ji G, Han A, Hao X, Li N, Xu R, Wang F. Better rotational control but similar outcomes with the outside-in versus the transtibial drilling technique foranterior cruciate ligament reconstruction: a systematic review of comparativetrials. Arch Orthop Trauma Surg. 2018 Nov;138(11):1575-1581.

(44) Inoue K, Deng Z, Chen Y, Giannopoulou E, Xu R, Gong S, Greenblatt MB, Mangala LS, Lopez-Berestein G, Kirsch DG, Sood AK, Zhao L, Zhao B. Bone protection by inhibition of microRNA-182. Nat Commun. 2018 Oct 5;9(1):4108.

(45) Debnath S, Yallowitz A, McCormick J, Lalani S, Zhang T, Xu R, Li N, Liu Y, Yang Y, Eiseman M, Shim J, Hameed M, Healey J, Bostrom M, Landau D, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation and fracture healing. Nature 2018 Oct;562(7725):133-139.  

(46) Xu R, Yallowitz A, Qin A, Wu Z, Shin D, Kim J, Debnath S, Ji G, Bostrom M, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos M, Wach A, Zhang Y, Inoue K, Lorenzo A, Zhao B, Butler J, Shim J, Glimcher L and Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss. Nature Medicine 2018 Jun;24(6):823-833.

(47) Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M, Davis RJ, Shim JH, Greenblatt MB. c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo. J Bone Miner Res. 2017 Sep;32(9):1811-1815.

(48) Chengshan Ma, Toru Fukuda, Hiroki Ochi, Satoko Sunamura , Cheng Xu, Ren Xu, Atsushi Okawa , Shu Takeda. Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling. Mol Metab . 2015 Jan 21;4(3):175-85. DOI: 10.1016/j.molmet.2015.01.002

(49) Xu R#. Semaphorin 3A: A new player in bone remodeling. Cell Adh Migr. 2014;8(1):5-10.

(50) Fukuda T*, Takeda S*, Xu R*, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations. Nature 2013 May 23;497(7450):490-3.

(51) Inose H,  Ochi H,  Kimura A,  Fujita K,  Xu R,  Sato S,  Iwasaki M,  Sunamura S,  Takeuchi Y,  Fukumoto S,  Saito K,  Nakamura T,  Siomi H,  Ito H,  Arai Y,  Shinomiya K,  Takeda S.  A microRNA regulatory mechanism of osteoblast differentiation. PNAS December 8, 2009vol. 106no. 49. DOI：10.1073/pnas.0909311106

(52) Mingzi Wang, Shaosong Liu, Yaoyao Li , Ren Xu , Chunhua Lu , Yuemao Shen*. Protoplast Mutation and Genome Shuffling Induce the Endophytic Fungus Tubercularia sp. TF5 to Produce New Compounds. Curr Microbiol (2010) 61:254–260  DOI 10.1007/s00284-010-9604-7

(53) Ren Xu, Ming-Zi Wang, Chun-Hua Lu, Zhong-Hui Zheng, and Yue-Mao Shen*. Tuberculariols A – C, New Sesquiterpenes from the Mutant Strain M-741 of Tubercularia sp. TF 5. Helvetica Chimica Acta – Vol. 92 (2009)

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