l 1997年9月-2001年7月, 四川大学，生命科学学院，学士
l 2001年9月-2006年7月, 中国科学院生物物理研究所，博士
l 2006年9月-2009年6月，美国新泽西州立大学，细胞与神经科学学系，博士后
l 2009年6月-2011年8月，美国新泽西州立大学，细胞与神经科学学系，研究助理
l 2011年8月-至今，纽约国际手机登录，教授，博士生导师
张杰博士长期从事重大神经系统疾病（老年痴呆、抑郁症、自闭症）等的发病机制和药物开发研究。至今以第一作者或者通讯作者在国际知名期刊发表研究论文30余篇。近几年作为通讯作者在Nature Neuroscience, Nature Metabolism, Neuron，Advanced Science, Biological Psychiatry, Cell Reports, PNAS, The Journal of Neuroscience, Clinical Cancer Research，Cell Death and Disease, JBC, Chemistry，Chem. Biol. Drug Des.等杂志上发表多篇研究论文。
l 国家自然科学基金 区域创新联合重点项目，己糖激酶和脂蛋白脂肪酶通过调控糖脂代谢在阿尔茨海默病发生发展中的作用及机制研究 U23A20430, 2024/01-2027/12, 260万
l 科技部重点研发计划 神经退行病变免疫微环境及神经干细胞调控与干预研究，2022/1-2026/12,骨干，200万
l 军队科技委173重点项目, 2020/11-2025/11, 骨干，320万
l 国家自然科学基金 器官衰老与器官退行性变化重大研究计划-集成项目，92149303 2022/01-2024/12，项目负责人，200万
l 国家杰出青年科学基金，阿尔茨海默病的分子机制研究，81925010，2020/01-2024/12，400万
l 国家自然科学基金 器官衰老与器官退行性变化重大研究计划-重点项目，胰岛素抵抗诱导神经元衰老及在老年痴呆发生发展中的作用、91849205，2019/01-2022/12，200万
l 国家自然科学基金 促进海峡两岸科技合作基金 重点项目，CDK3调控阿尔茨海默病中神经元死亡的机制及干预研究，U1905207，2020/01-2023/12，227万。
l 国家自然科学优秀青年基金，81522016、阿尔茨海默病的致病机制研究、2016/01-2018/12，150万
l 教育部“新世纪优秀人才”， 50万 NCET-13-0508
l 福建省“高等学校新世纪优秀人才”， 30万
l 福建省杰出青年科学基金，2014J06019、老年痴呆疾病中Cdk5调控因子P35和P25的神经功能差异研究、30万。
l 国家自然科学基金面上项目，81271421、阿尔茨海默病中CDK5对神经元细胞周期紊乱的作用和机制研究、70万
l 国家自然科学基金面上项目，31571055、Cdk5 磷酸化Bag3 及其在神经元突触功能和凋亡中的作用与机制研究，64万
l 福建省卫生教育联合攻关计划，40万
l 横向课题，“肌醇生物功效的深入开发研究”、200万
l 厦门大学校长基金、团队基金、交叉基金（250万）
l 2016-2019，国家重点研发计划 2016YFC1305900
遗传和环境因素交互作用下神经环路的沉默与早期AD发病 骨干
l 2014-2017，国家863项目 2015AA020502
活体多尺度结构成像系统与功能识别关键技术研究 骨干
l 中国生理学会 理事
l 中国神经科学学会 神经内分泌与稳态分会 副主任委员
l 中国神经科学学会 对外联络与宣传工作委员会 秘书长
l 中国生物物理学会 自由基医学分会 常务理事
l 中国老年学和老年医学学会 抗衰老分会 委员
l 中国医疗保健国际交流促进会 认知障碍分会 委员
l Pharmacological Research 编委
1. TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing. Chenli Li, Liangjie Wang, Wenting Xie, Erqu Chen, Yanbing Chen, Huifang Li, Dan Can, Aiyu Lei, Yue Wang, Jie Zhang*. Science Advances 2024 Jun 28;10(26):eado1855.
2. Lige Leng, Kai Zhuang, Hui Lin, Jinjun Ding, Shangchen Yang, Ziqi Yuan, Changquan Huang, Guimiao Chen, Zhenlei Chen, Mengdan Wang, Han Wang, Hao Sun, Huifang Li, He Chang, Zhenyi Chen, Qi Xu, Tifei Yuan, Jie Zhang* Menin reduces parvalbumin expression and is required for the anti-depressant function of ketamine. Advanced Science (Weinh), 2024 Feb;11(5):e2305659. doi: 10.1002/advs.202305659.
3. Zhuang K, Leng L, Su X, Wang S, Su Y, Chen Y, Yuan Z, Zi L, Li J, Xie W, Yan S, Xia Y, Wang H, Li H, Chen Z, Yuan T, Jie Zhang*. Menin Deficiency Induces Autism-Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1-Related Encephalopathy. Advanced Science (Weinh), 2024 Apr 6:e2307953. doi: 10.1002/advs.202307953
4. Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN-γ and PHGDH as a metabolic checkpoint of microglia polarization.Yang S, Yuan Z, Zhu Y, Liang C, Chen Z, Jie Zhang*, Lige Leng*. Brain Behav Immun. 2024 Mar;117:155-166
5. A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer disease. Yanbing Chen, Huimin Peng, Kai Zhuang, Wenting Xie, Chenli Li, Meiqin Chen, Jin Xue, Xiaoting Huang, Tingting Zou, Hao Sun, Aiyu Lei, Ya Wang, Dan Can, Huifang Li, Tifei Yuan, Jie Zhang* iScience 2024 Apr 19;27(5):109778.
6. Leng L, Yuan Z, Su X, Chen Z, Yang S, Chen M, Zhuang K, Lin H, Sun H, Li H, Xue M, Xu J, Yan J, Chen Z, Yuan T, Zhang Jie*. Hypothalamic Menin regulates systemic aging and cognitive decline. PLoS Biol. 2023 Mar 16;21(3):e3002033
7. Chen M, Wang C, Lin Y, Chen Y, Xie W, Huang X, Zhang F, Fu C, Zhuang K, Zou T, Can D, Li H, Wu S, Luo C, Zhang Jie*. Dorsal raphe nucleus-hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice. Transl Neurodegener. 2024 Jul 24;13(1):34.
8. Lige Leng, Ziqi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Bing Jin, Shengxi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang* Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to b-amyloid clearance Nature Metabolism, 2022 4(10):1287-1305
9. Wenting Xie , Dong Guo, Jieyin Li, Lei Yue, Qi Kang, Guimiao Chen, Tingwen Zhou, Han Wang, Kai Zhuang, Lige Leng, Huifang Li, Zhenyi Chen, Weiwei Gao, Jie Zhang* CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease. Cell Death Differ. 2022 2022 Dec;29(12):2417-2428
10. Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang* CDK5-dependent BAG3 degradation modulates synaptic protein turnover. Biological Psychiatry. 2019 Nov 21. (19)31865-7.
11. Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. Chow HM, Shi Meng, Cheng A, Gao Y, Chen G, Song X, So RWL, Jie Zhang*, Karl Herrup*. Nature Neuroscience. 2019 Nov;22(11):1806-1819.
12. Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu,* and Jie Zhang* Menin deficiency leads to depressive-like behaviors in mice by modulating astrocyte-mediated neuroinflammation. Neuron, 2018 Nov 7;100(3):551-563.e7
13. Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang* Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression. Cell Reports (2018) 24, 24, 701–712,
14. Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, Gao Y, Zhou J, Zhang Y, Bu G, Maoqiang Xue*, Jie Zhang* Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Cell Death Dis. 2018 Sep 20;9(10):951. doi: 10.1038/s41419-018-0983-1
15. Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Zhenyu Yin*, Zhang Jie*. CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis. J Exp Clin Cancer Res. 2019 Jul 4;38(1):286.
16. Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang* The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death. The Journal of Neuroscience 2015 Feb 11;35(6):2624-35
17. Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup Karl, Zhang Jie*. CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc Natl Acad Sci (USA). 2014 11, 111(45):E4887-95
18. Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu*, Yongliang Yang*, Changming Huang*, Jie Zhang* Cyclin dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clinical Cancer Research 2015 Mar 15;21(6):1419-1428
19. Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang*, Yongliang Yang * Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE. Chem. Biol. Drug Des. 2014 Jan;83(1):81-88.
20. Kang YF, Yan WJ, Zhou TW, Dai F, Li XZ, Bao XZ, Du YT, Yuan CH, Wang HB, Ren XR, Liu Q, Jin XL, Zhou B*, Zhang Jie*. Tailoring 3,3'-dihydroxyisorenieratene to hydroxystilbene: finding a resveratrol analogue with increased antiproliferation activity and cell selectivity. Chemistry. 2014 Jul 14;20(29):8904-8.
21. Zhang Jie*, Li Huifang, Zhou Tingwen, Zhou Jiechao, Herrup Karl. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase, J Biol. Chem. 287(31), 25985-94 (2012). (*Corresponding authors)
22. Niu Yaqiong, Li Huifang, Herrup Karl and Zhang Jie*, Neuronal Cell Cycle Regulation of Cdk5 in Alzheimer’s Disease. Brain Disord. Ther. 1:3 (*corresponding author) (2012).
23. Zhang Jie, Herrup K, Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle 10(8) 1208-14 (2011).
24. Zhang Jie, Huifang Li, Herrup Karl. Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. The Journal of Neuroscience 30, 5219-5228 (2010).
25. Zhang Jie, Huifang Li, Herrup Karl. Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation, J. Biol. Chem. 285(18), 14052-61 (2010).
26. Zhang Jie, Cicero, S.A., Wang, L., Romito-Digiacomo, R.R., Yang, Y. and Herrup, K, Nuclear localization of Cdk5 is a key determinant in the post-mitotic state of neurons. Proc. Nat. Acad. Sci. (USA) 105, 8772-8777 (2008).
27. Zhang Jie, Herrup Karl. Cdk5 and the non-catalytic arrest of the neuronal cell cycle, Cell Cycle 7:3487-90 (2008).
28. Liu Qiang*, Zhang Jie*, Zhu Hua, Qin Chuan, Chen Qi and Zhao Baolu Zhao, Dissecting the signaling pathway of nicotine-mediated Nneuroprotection in amouse Alzheimer disease model. FASEB J. 21(1), 61-73(*Equal contribution) (2007).
29. Zhang Jie, Liu Qiang, Liu Nian-Qing, Li Fu-Liang, Chen Qi, Qin Chuan, Zhu Hua, Huang Yu-Ying, He Wei, Zhao Bao-Lu, Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J. 20(8), 1212-4 (2006).
30. Zhang Jie, Mori Akitane, Chen Qi, Zhao Bao-Lu, Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Neuroscience 143(1), 63-72 (2006).
31. Zhang Jie, Wang Xue-Fei, Lu Zhong-Bing, Liu Nian-Qing, Zhao Bao-Lu, The effects of meso-2, 3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. Free Radic. Biol. Med. 37, 1037-1050 (2004).
